Lijiao Zhao Selected Research

Nimustine

12/2021	Development and biological evaluation of AzoBGNU: A novel hypoxia-activated DNA crosslinking prodrug with AGT-inhibitory activity.
2/2017	Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.
5/2016	Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O(6)-alkylguanine-DNA alkyltransferase.
1/2015	Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry.
7/2014	Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry.
3/2014	Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.

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Lijiao Zhao Research Topics

Disease

24	Neoplasms (Cancer) 01/2022 - 07/2011
6	Glioma (Gliomas) 01/2020 - 07/2014
4	Carcinogenesis 11/2020 - 10/2013
3	Hypoxia (Hypoxemia) 12/2021 - 01/2019
2	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2015
2	Leukemia L1210 01/2015 - 03/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2022
1	Liver Neoplasms (Liver Cancer) 01/2021
1	Hyperthermia 11/2020
1	Sepsis (Septicemia) 11/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2020
1	Hyperplasia 10/2011

Drug/Important Bio-Agent (IBA)

10	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 07/2014
9	Alkylating AgentsIBA 01/2020 - 07/2011
6	Carmustine (FIVB)FDA Link 01/2022 - 01/2015
6	NimustineIBA 12/2021 - 03/2014
5	O(6)-benzylguanineIBA 12/2021 - 07/2014
4	ProdrugsIBA 12/2021 - 01/2018
4	MethyltransferasesIBA 01/2020 - 06/2016
3	N-(2-chloroethyl)-N-nitrosoacetamideIBA 12/2021 - 01/2015
3	Alkyl and Aryl TransferasesIBA 12/2021 - 01/2019
3	Casein Kinase II (Casein Kinase 2)IBA 01/2020 - 05/2017
3	bromopyruvateIBA 01/2020 - 03/2019
3	GuanineIBA 10/2016 - 01/2015
2	Biological ProductsIBA 12/2021 - 03/2019
2	SmokeIBA 11/2020 - 01/2020
2	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA 11/2020 - 01/2020
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 01/2020
2	DNA AdductsIBA 01/2020 - 10/2013
2	NitrosaminesIBA 01/2020 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2020 - 03/2019
2	Pharmaceutical PreparationsIBA 01/2019 - 01/2018
1	Tyrosine (L-Tyrosine)FDA Link 03/2022
1	Phosphotransferases (Kinase)IBA 03/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2022
1	Glutathione (Reduced Glutathione)IBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	azobenzeneIBA 12/2021
1	Formaldehyde (Formol)FDA Link 01/2021
1	ParaffinIBA 01/2021
1	AnionsIBA 01/2021
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2020
1	lonidamineIBA 11/2020
1	Urea (Carbamide)FDA LinkGeneric 11/2020
1	Hemoglobins (Hemoglobin)IBA 11/2020
1	PotassiumIBA 11/2020
1	NitrogenIBA 11/2020
1	Caspase 3 (Caspase-3)IBA 11/2020
1	FlavonoidsIBA 11/2020
1	Anticarcinogenic AgentsIBA 11/2020
1	ApigeninIBA 11/2020
1	Cyclin D1IBA 11/2020
1	EstersIBA 01/2020
1	O-(6)-methylguanineIBA 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2020
1	AcidsIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2020
1	XanthineIBA 12/2019
1	Glucose OxidaseIBA 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 12/2019
1	Xanthine OxidaseIBA 12/2019
1	Oxidoreductases (Dehydrogenase)IBA 12/2019
1	CatalaseIBA 12/2019
1	Fluorouracil (Carac)FDA LinkGeneric 03/2019
1	Antineoplastic Agents (Antineoplastics)IBA 03/2019
1	Daunorubicin (Cerubidine)FDA LinkGeneric 03/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2019
1	Cisplatin (Platino)FDA LinkGeneric 03/2019
1	CarcinogensIBA 01/2019
1	N'-nitrosonornicotine (nitrosonornicotine)IBA 01/2019
1	isoliquiritigenin (GU 17)IBA 01/2019
1	silmitasertibIBA 01/2019
1	AminesIBA 01/2019
1	Phosphates (Orthophosphate)IBA 01/2019
1	Benzoic Acid (Potassium Benzoate)FDA Link 01/2019
1	DNA Repair EnzymesIBA 06/2016
1	calf thymus DNAIBA 05/2016
1	fotemustine (Muphoran)IBA 01/2015
1	Lomustine (CCNU)FDA Link 01/2015
1	CytosineIBA 01/2015
1	IsotopesIBA 07/2014
1	Biomarkers (Surrogate Marker)IBA 10/2013
1	Phenobarbital (Luminal)FDA Link 10/2011

Therapy/Procedure

7	Drug Therapy (Chemotherapy) 12/2021 - 06/2016
1	Photochemotherapy (Photodynamic Therapy) 11/2020
1	Radiotherapy 11/2020
1	Physical Therapy Modalities (Physical Therapy Technique) 11/2020
1	Therapeutics 05/2017
1	Stents 10/2011